Morphological aberration in Control and Treated Groups. Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE). Morphol., 27(1):7-11, 2009. [Amy Zmarowski, Manon Beekhuijzen, Joost Lensen, Harry Emmen] PMID 22664268 Wistar Institute (USA) Han Wistar breeding movement Wistar breeding movement 1995 2004 1982 1968 1989 1994 1993 1996 The Wistar Hannover source colony was originally ... Wistar Hannover rats make it an exceptional strain for carcinogenicity testing, relative to … Furthermore, concern has been expressed that children might be at higher risk to acrylamide due to Each member of GALAS received 50 breeding stock from RCC in 1998. The substrains of Wistar rats: Wistar Hannover (Han/Wistart) and Wistar Unilever (WU) rat are outbred; while Wistar Kyoto and Wistar … The incidence of adenocarcinoma, while higher in SD strains, varies dramatically between different SD strains/suppliers, with approximately 22% reported in Crl: CD(SD) rats ( Charles River 2004 ) compared with 13% in Hsd: SD rats … Wistar Han RCC rats at the end of both feeding trials The mycotoxins fumonisin B1, fumonisin B2 and deox- reached a value of about 410–430 g/animal, while that of ynivalenol were detected in some of the diets, although at the female rats was about 250 g/animal. The data from Wistar Han rats were compared with those from Sprague Dawley Crl:CD(SD) rats. rats [14], but published historical data on wistar Han-nover rats relating to a general toxicity study are scarce [21]. Multivariate t-pattern analyses demonstrated a very different temporal profile of behavior in the two strains: Wistar rats presented 197 t-patterns of different composition, whereas DA/Han rats only 26; as to the mean number of t-patterns, Wistar presented a value of 698.90, whereas DA/Han only 92.80. Han/Wistar (Kuopio ) rats have a mutated AhR (AhR hw/hw) while Long‐Evans rats have wild type AhR (AhR wt/wt) (Pohjanvirta et al . Thus, these findings support the use of Wistar Han RCC rats in chronic toxicity and carcinogenicity studies. Table II. Popularity of Han Wistar rats – reproductive toxicity studies UK* Studies completed 2009 – 2013 * Main plus preliminary studies combined count. Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: differences in baseline behavior and reactivity to positive control agents Reprod Toxicol . We report here the oncogenic response of Wistar Han rats to orally administered acrylamide. 2011 ). ... Wistar is outbred (as is Wistar Han, Wistar unilever...), but Wistar Furth, Wistar Kyoto etc are inbred. and Wistar Han rats, and WBC and AST were lower than those in the ad libitum fed SD rats. 5-week-old male and female Wistar Han RCC rats were pur - chased from Harlan (San Pietro al Natisone, Italy). Outbred Rats - RccHan:WIST - 168. Incidences of Neoplasms and Non-neoplastic Lesions of the Testis and Ovary in Wistar Han Rats in the Two-year Gavage Study of Tetrabromobisphenol A .....40 Table 8. Not all people looking for information on Wistar Rats are looking for information on Lab Rats in general, not to mention an image of a dissected one. Wistar Han rats were selected due to their longevity and low incidence of Leydig cell tumors. Our researchers recently completed a two-year study of 130 male and 130 female Envigo RccHan®:WIST (Wistar Han®) rats and compared them to other outbred rats (e.g., Sprague-Dawley®, Fischer 344).Here, we share the results of the study. Differences in the incidences of fetal malformations have also been shown to occur between Han/Wistar (Kuopio ) rats and Long‐Evans rats … Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional Origin: Derived at Biological Research Laboratories Limited (BRL), formerly RCC, now Harlan Laboratories Ltd., Füllinsdorf, Switzerland from original colony at Zentralinstitute für Versuchstierzucht, Hannover in 1989. To explain this apparent sex-dependence, the disposition and toxicokinetic profile of TBBPA were investigated using female Wistar Han rats, as no data were available for female rats. Wistar rats: ( wis'tehr ), an inbred strain of rats, homozygous at most loci, produced by strict brother-sister inbreeding over many generations to develop animals for research with the same general genetic composition. 2012 Sep;34(2):192-203. doi: 10.1016/j.reprotox.2012.05.091. II: Chronic Dosing Causes Developmental Delay Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: differences in baseline behavior and reactivity to positive control agents. Toxicol Pathol. Furthermore, age-related changes and sex differ-ences in serum chemistry values in sd rats have been reported [18]. The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Taconic received breeding stock from RCC in 1998. Both the incidence and severity of this change were higher in Han Wistar than in Sprague-Dawley rats. At gestation day (GD) 6, pregnant dams were provided acrylamide in their drinking water. We report here the oncogenic response of Wistar Han rats to orally administered acrylamide. In addition, the effects of restricted feeding of SD rats were also investigated by one facility. Survival and Body Weights of Mice in the Three-month Gavage Study of J. Sperm positive female Wistar Han/RccHan:WIST rats were obtained from Harlan Laboratories GmbH, Serumweg 48, 27324 Eystrup, Germany in multiple deliveries. OYEYEMI, M. O. 2018 Jul;92(7):2385-2399. doi: 10.1007/s00204-018-2230-z. It has the distinct honor of being the first rat stock developed to serve as a model animal. Epub 2018 May 31. The study design, the performance and the results of the feeding trials Table 1 Maize variety content of the different diets used in the rat feeding trials D and E aNear-isogenic maize variety of DKC6667 YG, from Monsanto While developmental exposure to TCDD has toxic effects, our data have shown no potent adverse effects on epididymal sperm levels or the weights of accessory sex organs. & ADENIJI, D. A. Morphological characteristics and haematological studies in Wistar rats subjected to prolonged treatment of chloramphenicol. occurs more commonly in Han Wistar rats. Abstract: Adult male Han/Wistar rats were administered 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) intraperitoneally at doses ranging from 125 to 1400 μg/kg and monitored for 39 to 48 days. Wistar Han Rats in the Two-year Gavage Study of Tetrabromobisphenol A .....37 Table 7. Taconic replaced its previous Wistar Hannover stock with Wistar Hannover … An outbred Wistar rat strain (CRL:WI(Han)) was used to ensure comparability with (1) previous use of Wistar rats (Faqi et al., 1998) and (2) extensive in-house experience with this strain. [ Wistar Institute] Two rats succumbed in the course of the experiment: one in the group receiving 625 and one dosed 1000 μg/kg. Haematological results of Wistar rats treated with chloramphenicol. 1998 ; Sakamoto et al. Table III. Arch Toxicol. As a result, body weights and food consumption in Wistar Han rats were lower than those of SD rats. Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th Framework Programme project GRACE). Key words:Wistar Hannover rat, Sprague Dawley rat, Background data, General toxicity In both strains, females were more affected, but the sex difference was Table 1: Incidence and cellular distribution of pigment deposits in the liver of Han Wistar rats in short term studies. Wistar rat is another common hybrid albino model animal. The data that have been presented for Wistar strains show a lower incidence of fibroadenoma in Crl: WI(Han) rats when compared to RccHan ™: WIST rats. Chronic prostatitis characterized on light microscopic examination by moderate, multifocal, predominantly lymphocytic inflammation associated with epithelial atypia and … Furthermore, concern has been expressed that children might be at higher risk to acrylamide due to greater dietary acrylamide intake (EPA Science Advisory Board, 2008). Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. 1. One conventional 2-fed female rat developed a pituitary haemangioma and one 11 % GMO-fed female rat a yolk sac carcinoma, a rare spontaneous neoplasm of germ cell origin (Sobis 1987 ; Nakazawa et al. Int. The rats were refreshed with cryopreserved embryos in 1998. The rats were derived by caesarean in 1999. 1998). therefore, collection of general toxico-(Received 23 August 2011 / … Average and Range Weights Male and Female Wistar and Sprague Dawley Rats from 3 to 12 Weeks held at ARC (updated yearly) Average and Range of Weights (g) of Commonly Used Strains of Mice* Wistar Han rats were selected due to their longevity and low incidence of Leydig cell tumors. Use an outbred stock of rat such as the Wistar Han or the Sprague Dawley NTP temporarily switched to the F344/NTac rat and then selected the Wistar Han rat [Crl:WI (Han)]. 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