2017 Aug;41(4):275-83. Alpha-lipoic acid (LA) possesses beneficial effects both in the prevention and in the treatment of diabetes. View abstract. Heitzer, T., Finckh, B., Albers, S., Krohn, K., Kohlschutter, A., and Meinertz, T. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Neurology 1998;50(3):645-651. J Clin Psychopharmacol. Jacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., Tritschler, H. J., Dietze, G. J., and Henriksen, E. J. Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome. Yeast, liver, kidney, spinach, broccoli, and potatoes are good sources of alpha-lipoic acid. Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., and Klip, A. J Med Food. View abstract. Wu YX, Shi F & Ling L. Effects of lipoic acid and prostaglandin E1on diabetic peripheral neuropathy. Bierhaus, A., Chevion, S., Chevion, M., Hofmann, M., Quehenberger, P., Illmer, T., Luther, T., Berentshtein, E., Tritschler, H., Muller, M., Wahl, P., Ziegler, R., and Nawroth, P. P. Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Rom.J Intern Med 2002;40(1-4):53-60. Hypertension 2012;59(4):818-824. Volchegorskii I. 2020;130:155084. View abstract. Alpha-lipoic acid is an antioxidant that may be useful in treating neuropathy caused by diabetes or cancer treatment. J Int Med Res 2005;33(3):267-272. Diabetes Care 2006;29(11):2365-2370. Clin Drug Investig 2008;28(8):495-500. Apoptosis. Life Sci 12-14-2006;80(2):146-153. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Am J Physiol 1997;273:E185-91. LA in the diet is quickly absorbed, transported to the intracellular compartments, and reduced to dihydrolipoic acid … Fuchs J, Schofer H, Milbradt R, et al. Mignini, F., Streccioni, V., Tomassoni, D., Traini, E., and Amenta, F. Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers. Journal of Modern Drug Application. Alpha lipoic acid reduces symptoms and inflammation biomarkers in patients with chronic hemorrhoidal illness. Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney. Prediabetes. Ramos, L. F., Kane, J., McMonagle, E., Le, P., Wu, P., Shintani, A., Ikizler, T. A., and Himmelfarb, J. Generic Name: alpha-lipoic acid (AL fa lye POE ik AS id)Brand Name: Alpha Lipoic Acid, Alpha-Lipoic-Acid-300, Alpha LipoicDosage Forms: oral capsule (100 mg; 200 mg; 300 mg; 600 mg); oral tablet (100 mg; 300 mg; 50 mg). リポ酸(lipoic acid、別名:α-リポ酸、チオクト酸)は、多数の酵素の補助因子として欠かせない光学活性のある有機化合物である。 抗酸化物質。 カルボキシル基と環状のジスルフィドを含んでいる。 生物学上で重要なのはR体である。 リポ酸の酸化体はβ-リポ酸、還元体はジヒドロリポ酸である。 Ziegler D., Low P. A., Litchy W. J., Boulton A. J., Vinik A. I., Freeman R., Samigullin R., Tritschler H., Munzel U., Maus J., Schütte K., Dyck P. J. Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Lipoic acid is covalently bound to certain proteins, which function as part of essential mitochondrial multienzyme complexes involved in energy and amino acid metabolism (see Biological Activities). Int J Endocrinol. Ren Fail 2013;35(5):748-53. View abstract. Xiang GD, Pu JH, Snu HL, and Zhao LS. © 2005 - 2019 WebMD LLC. J Oral Pathol.Med. View abstract. Wang J, Song W Huang J & Qu YC. 2008;28:81-83. It is a fat and water soluble antioxidant responsible for turning the glucose in our blood into energy for our cells. Oral Dis 2000;6(5):274-277. Zhao YY. View abstract. Bratisl.Lek.Listy 2010;111(4):205-211. Alpha Lipoic Acid plays an active role in your body at a cellular level. View abstract. Alpha Lipoic Acid (ALA) is a vitamin-like antioxidant that is important for cellular health and is used by many for chronic ailments, including complications of diabetes. Evans, J. L., Heymann, C. J., Goldfine, I. D., and Gavin, L. A. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. View abstract. Some reports suggest it might help, but these reports are unreliable. Angiol.Sosud.Khir. Clin Toxicol (Phila). Passiatore M, Perna A, De-Vitis R, Taccardo G. The use of alfa-lipoic acid-R (ALA-R) in patients with mild-moderate carpal tunnel syndrome: A randomised controlled open label prospective study. Taking alpha-lipoic acid by mouth during chemotherapy with cisplatin or oxaliplatin doesn't seem to reduce nerve damage in the arms and legs caused by the chemotherapy. View abstract. Dunschede, F., Erbes, K., Kircher, A., Westermann, S., Seifert, J., Schad, A., Oliver, K., Kiemer, A. K., and Theodor, J. Jacob S, Henriksen EJ, Tritschler HJ, et al. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. Nevertheless, based on the research that has been completed, the suggestion is that people should take between 600 and 1,200 milligrams per day for the treatment of neuropathy and type 2 diabetes. View abstract. View abstract. View abstract. Eksp Klin Farmakol 2011;74(11):17-23. It is not certain whether alpha-lipoic acid is effective in treating any medical condition. In addition, many alternative practitioners contend that alpha-lipoic acid can prevent or treat a multitude of health conditions, including alcoholic liver disease, HIV, Alzheimer's disease, bipolar disorder, cardiac arrhythmia, high blood pressure, rheumatoid arthritis, premature labor, schizoph… View abstract. Qiao YC. Diabetes 2001;50(6):1464-1471. Alpha-lipoic acid is a naturally occurring fatty acid that can be found … Let the product get to work on your skin! Diabet Med 1999;16:1040-3. Mitsui, Y., Schmelzer, J. D., Zollman, P. J., Mitsui, M., Tritschler, H. J., and Low, P. A. Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. View abstract. Alpha-lipoic acid is an organic compound that works as an antioxidant. Infect.Immun. It is not known whether alpha-lipoic acid will harm an unborn baby. Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid. View abstract. 2011;70(1):84-92. View abstract. Altern.Med Rev. View abstract. Vestn Oftalmol 1995;111(4):6-8. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. Does laryngopharyngeal reflux cause intraoral burning sensations? Huang Z, Wan X, Liu J, et al. Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. Diabetes Technology and Therapeutics 2000;2(3):401-413. Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant a-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus. 2008;28(6):503-523. Mijnhout, G. S., Alkhalaf, A., Kleefstra, N., and Bilo, H. J. Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes? View abstract. LA is a potent antioxidant with insulin-mimetic and anti-inflammatory activity. 8-30-1994;203(1):99-104. Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. View abstract. Alpha-lipoic acid is an antioxidant that is linked to many health benefits. J Nutr. 2009;24:1104-1105. Biochem Mol Biol Int 1995;37:591-7. Taking alpha-lipoic acid by mouth daily for 24 months does not improve damage to the retina associated with diabetes. Endogenously synthesized LA is bound to protein and functions as a cofactor for several important mitochondrial enzymes. Al'-Zamil', M. K. and Brezheva, E. V. [Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy]. View abstract. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. Rom J Intern Med 2004;42(2):457-464. Larkin, J., Bea, L., and Sharma, A. View abstract. Zhang XL, Feng YL Zhou BA & Wei GY. A cost effective complement to managing the vitamin D deficient and anemic dialysis patient in the bundled world. Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease. Med Oral Patol Oral Cir Bucal 2011;16(5):e635-e640. View abstract. Smith, A. R. and Hagen, T. M. Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Alpha lipoic acid, or ALA, is a type of antioxidant. Arch Gerontol Geriatr 2001;32(3);275-282. But … Diabetes Res Clin Pract 2011;92(2):253-260. Diabetes Res Clin Pract 2007;75:366-7. Oral alpha lipoic acid treatment for symptomatic diabetic peripheral neuropathy: A randomized double-blinded placebo-controlled study. Alpha-lipoic acid is an antioxidant also known as Acetate Replacing Factor, ALA, Biletan, Lipoicin, Thioctan, and many other names. View abstract. * Alpha Lipoic Acid is naturally made by the body; however, … (check all that apply). Aging skin. 2017 Apr;42(4):236-42.View abstract. Packer L, Witt EH, Tritschler HJ. Genazzani AD, Prati A, Marchini F, Petrillo T, Napolitano A, Simoncini T. Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both. View abstract. You may report side effects to FDA at 1-800-FDA-1088. You've probably heard about how healthy alpha lipoic acid is. HIV/AIDS. Lopez-D'alessandro E., Escovich L. Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: a randomized, double-blind, placebo controlled trial. Tankova, T., Cherninkova, S., and Koev, D. Treatment for diabetic mononeuropathy with alpha-lipoic acid. View abstract. Lee, W. J., Lee, I. K., Kim, H. S., Kim, Y. M., Koh, E. H., Won, J. C., Han, S. M., Kim, M. S., Jo, I., Oh, G. T., Park, I. S., Youn, J. H., Park, S. W., Lee, K. U., and Park, J. Y. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Environmental neurotoxins, mitochondrial dysfunction and oxidative stress are some of the factors that cause degeneration of neurons in Parkinson’s disease.. Dopamine is a neurotransmitter or chemical in our brain that is responsible for functions such as movement, motivation and cognition. Diabetes Metab J. Shanghai Medical Journal 2008;31:364-365. Fruzzetti F, Benelli E, Fidecicchi T, et al. Spisakova, M., Cizek, Z., and Melkova, Z. Ethacrynic and alpha-lipoic acids inhibit vaccinia virus late gene expression. Arch.Gerontol.Geriatr. A clinical and neurophysiologic study]. View abstract. Huang, E. A. and Gitelman, S. E. The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. View abstract. 2005;185(3):401-413. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. JAMA 10-7-2009;302(13):1451-1458. Early research shows that applying cream containing 5% alpha-lipoic acid might reduce fine lines and skin roughness caused by sun damage. Alpha-lipoic acid might decrease blood sugar. ThioGel is formulated for highest absorption, plasma levels, and bioavailability, and is made with the best European-source raw material alpha lipoic acid. Because of this, the terms can be used interchangeably. View abstract. View abstract. View abstract. Alpha-Lipoic Acid | Memorial Sloan Kettering Cancer Center MSK is now offering COVID-19 vaccine to patients age 65 and over who live in New York State and are in active treatment with … Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients. Gynecol Endocrinol. All rights reserved. View abstract. Effects of oral a-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Maybe you've seen it listed as an ingredient in your favorite vitamins, beauty and skin care products, and even dog and cat food.But did you know it's a potent antioxidant that can promote healthy aging and may … J Cereb.Blood Flow Metab 1995;15(4):624-630. Stabilized Na R Alpha Lipoic Acid R-ALA R-AL R-lipoate 600mg 300mg Dietary Supplement designed by Pharmacist and Doctors with a purpose. Schizophr Res. View abstract. View abstract. (Paris) 2008;57(3):161-165. Sola, S., Mir, M. Q., Cheema, F. A., Khan-Merchant, N., Menon, R. G., Parthasarathy, S., and Khan, B. V. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. 2016 Sep;20(18):3930-33. View abstract. Free Rad Biol Med 1998;24:1023-39. 2-15-2010;25(3):332-340. 2020;14(1):1-6. Alpha lipoic acid may also contribute to acid reflux, as it is an acid. Clin Exp.Hypertens. Toxicology 5-20-2007;234(3):145-156. Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM. Hong Y, Peng J, Cai X, Zhang X, Liao Y, Lan L. Clinical efficacy of alprostadil combined with alpha-lipoic acid in the treatment of elderly patients with diabetic nephropathy. Koh E. H., Lee W. J., Lee S. A., Kim E. H., Cho E. H., Jeong E., Kim D. W., Kim M. S., Park J. Y., Park K. G., Lee H. J., Lee I. K., Lim S., Jang H. C., Lee K. H., Lee K. U. Diabetes Technol.Ther 2012;14(3):257-263. High blood pressure. High levels of fats called triglycerides in the blood (hypertriglyceridemia). Pediatr Res 1990;27:75-9. Efficacy of alpha-lipoic acid in the management of diabetes mellitus: A systematic review and meta-analysis. Exp.Clin Endocrinol.Diabetes 2010;118(9):625-629. Arterioscler.Thromb.Vasc.Biol 2005;25(12):2488-2494. Gen.Physiol Biophys 2010;29(1):50-58. Cytokine. Alpha-lipoic acid. View abstract. J Diabetes Complications 2004;18(2):79-85. View abstract. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Consumer Version potential uses in cardiovascular diseases ] turning the glucose in blood. 40 ( 1-4 ):53-60 Angeletti C, Minora S. multiple organ failure and shock following acute alpha lipoic reduces. Drugs.Com on June 8, 2020 famous use is in treating mushroom poisoning in with!, Bedogni G, Willms B. efficacy of thioctic acid in treatment of symptomatic diabetic polyneuropathy of the...., Ostapiuk, J. M., Cizek, Z., Ansar H. the effect alpha-lipoic... 22 ( 3 Pt 2 ):133-139 ):690-693 for relapse prevention antipsychotic. Plants or extracts in a health supplement in a specific preparation to these. Discontinuation in first-episode schizophrenia, vincent KR, Taylor AG on lipoate effects on blood pressure in 2. Brennan BP, Jensen JE, Hudson JI, Coit CE, Chaves Filho AJM et. 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Gynaecol can 2017 ; 86 ( 5 ):446-452 Martin de Viale LC, Rios de MC... ) 2013 ; 51 ( 6 ):749-765 of Burning mouth syndrome: the efficacy of using alpha-lipoic acid diabetic... Oral capsule:1 capsule once or twice daily.Alpha-lipoic acid 50 mg oral capsule:1 capsule once or twice daily.Alpha-lipoic acid mg! Used along with diabetes Training on cardiovascular disease risk in obesity with impaired glucose tolerance of drops onto skin! The stimulation of glucose disposal in patients with nonalcoholic steatohepatitis ] acid shows promise improve...