Call your doctor for medical advice about side effects. You may report them to the FDA. Please report all side effects to the doctor or nurse. This content does not have an Arabic version. For intravenous use only; fatal if given by other routes. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. There are several things you can do to prevent or relieve constipation. Erythromycin is an inhibitor of CYP3A4 and also inhibits P-gp. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. Jaw pain, pharyngeal pain, parotid gland pain, bone pain, back pain, limb pain, and myalgias have been reported; pain in these areas may be severe. Vincristine may also cause a number of alternate side effects. Common and Rare Side Effects Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. We comply with the HONcode standard for trustworthy health information -, FDA Updates Vinca Alkaloid Labeling for Preparation in Intravenous Infusion Bags Only, hallucinations (seeing, hearing, or feeling things that are not there). These and others are described below. Nausea 2. Side Effects Drug information provided by: IBM Micromedex Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. If experienced, these tend to have a Severe expression 1. Taking Vincristine may lead to serious side effects if you are breastfeeding. It is common for people to experience some side effects in receiving this drug, but not everybody will experience side effects. Last updated on May 28, 2020. An Increase In Uric Acid Due To Cancer Chemotherapy 3. You should not use this medication if you have a nerve-muscle disorder, such as Charcot-Marie-Tooth syndrome, myasthenia gravis, ALS (Lou Gehrig's disease), multiple sclerosis , or muscular dystrophy. This site complies with the HONcode standard for trustworthy health information: verify here. Liver damage Vincristine may react with other drugs in your pet's system to causesignificant organ damage, particularly to the liver. The mechanism of this side effect is largely unknown but it is believed to be due to the effect of the drug on the autonomic nervous system. To reduce the potential for fatal medication errors due to incorrect route of administration proper dilution, product labeling and packaging is necessary. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The drug can interact with the pet’s nervous system and can give rise to seizures and neurological disorders. Intravenous needle or catheter must be properly positioned before any vinCRIStine is injected, as leakage into the surrounding tissue may cause considerable irritation. A Skin Rash 2. Side Effects of Vincristine As with most other chemotherapy drugs, there are a few side effects associated with the use of Vincristine . There is no relationship between the presence or severity of side effects and the effectiveness of Vincristine. Numbness of the fingers and toes, atrophy, cramps, slapping gait, and difficulty in walking or inability to walk, may occur. These are generally milder than those listed above and include: 1. "Product Information. Vomiting 5. This page from Great Ormond Street Hospital (GOSH) explains what vincristine is, how it is given and some of the possible side effects. Vincristine lipid injection may cause other side effects. Read more about the prescription drug VINCRISTINE - INJECTION. If you experience a serious side … Check with your doctor immediately if any of the following side effects occur while taking vincristine: Check with your doctor as soon as possible if any of the following side effects occur while taking vincristine: Some side effects of vincristine may occur that usually do not need medical attention. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects may occur that usually do not need medical attention. Frequently, there is a sequence to the development of neuromuscular side effects. Vincristine is a chemotherapy medicine that is used to treat certain types of cancer. Call your doctor if you have any unusual problems while taking this medication. Tummy (abdominal) pain Vincristine can temporarily stop the normal muscle contractions of the bowel. All rights reserved. Disorientation 3. The following side effects are common (occurring in greater than 30%) for patients taking Vincristine: Hair loss (in 20-70% of patients) may be partial or complete hair loss Vincristine can cause serious constipation, abdominal pain and can even lead to a blockage or stoppage of the bowel (called paralytic ileus) if not treated promptly. Vincristine, a chemotherapeutic agent, in combination with azole antifungals, has shown to increase adverse drug reactions. This medicine often causes a temporary loss of hair. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This content does not have an English version. [Ref], Frequency not reported: Depression, agitation, insomnia, hallucinations[Ref], In general, adverse reactions are reversible and are related to dosage size and cumulative dosage. Teva SICOR Pharmaceuticals Inc, Irvine, CA. Loss of deep-tendon reflexes, foot drop, wrist drop, ataxia, and paralysis have been reported with continued administration. Since the growth of normal body cells may also be affected by vincristine, other effects will also occur. Discuss these possible effects with your doctor. Vincristine Sulfate Side Effects See also Warning section. The most common adverse reactions that have been reported include gastrointestinal toxicity, peripheral neuropathy, electrolyte abnormalities, cranial neuropathy and seizures. All rights reserved. Peripheral Sensory Nerve Disorde… Applies to vincristine: intravenous solution. Low Levels Of White Blood Cells 5. Side Effects See also Warning section. Nausea, vomiting, weight loss, diarrhea, mouth sores, dizziness, or headache may occur. The use of small amounts of this drug daily for long periods is not advised. Low Amount Of Sodium In The Blood 4. Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. Serious side … Call your doctor right away if any of these effects bother you, do not go away, or get very bad. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Vincasar PFS (vinCRIStine)." © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Call your doctor if you have any unusual problems while receiving this medication. Vincristine interferes with the growth of cancer cells, which are eventually destroyed. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. Nausea 5. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Vincristine is … These and others are described below. Most people experience some side effects from vincristine treatment. prednisone, methotrexate, Keytruda, fluorouracil, rituximab, Imbruvica, Revlimid, carboplatin, cyclophosphamide, Rituxan. Gas 4. Oncovin (vincristine) has a toxic profile that is pretty well understood. Vincristine is a chemotherapy drug. Initially, only sensory impairment and paresthesia, may develop. Mayo Clinic does not endorse companies or products. Severe constipation with abdominal pain occurs in 1 in 3 people (around 33%) who have vincristine. The following are some of the most common side effects of vincristine: Hair loss, which may affect all or only some of your hair Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects may occur that usually do not need medical attention. These are … Urinary stones and kidney problems: This is due to the effect of chemotherapy on cancer cells. Nausea, vomiting, weight loss, diarrhea, mouth sores, dizziness, or headache may occur. Copyright © 2021 IBM Watson Health. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Vincristine may cause other side effects. It is a treatment for different types of cancer. If you notice any other effects, check with your healthcare professional. Applies to vincristine: compounding powder, intravenous solution, Frequency not reported: Acute shortness of breath, severe bronchospasm, dyspnea[Ref], Common (1% to 10%): Constipation (may take the form of upper colon impaction), paralytic ileus, abdominal cramps, Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, anorexia, stomatitis, oral ulceration, intestinal necrosis and/or perforation, abdominal cramps, abdominal distension, weight loss, Frequency not reported: Paralytic ileus (particularly in young children and in the elderly), pancreatitis[Ref], Frequency not reported: Anemia, leukopenia, thrombocytopenia[Ref], Frequency not reported: Hypertension, hypotension[Ref], Frequency not reported: Transient cortical blindness, optic atrophy with blindness, diplopia, ptosis, photophobia, visual hallucinations[Ref], Frequency not reported: Polyuria, oliguria, nocturia, dysuria, urinary retention, testicular pain[Ref], Frequency not reported: Second malignancies[Ref], Rare (0.01% to 0.1%): Allergic-type reactions (e.g., anaphylaxis)[Ref], Frequency not reported: Hepatic veno-occlusive disease, hepatitis[Ref], Frequency not reported: Neurotoxicity is the most common dose-limiting side effect of this drug. 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