2020 Mar 9;10(1):90. doi: 10.1038/s41398-020-0767-0. 1988 Nov;37(11):1549-58. doi: 10.2337/diab.37.11.1549. In ZDF rats, a mutation in the leptin receptor, OB-R, is associated with leptin resistance, obesity, and increased fat content of islets. 1991 Oct;261(4 Pt 2):R912-9.  |   |  Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555. Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine. Please enable it to take advantage of the complete set of features! Am J Physiol. In vivo effects of insulin and bis(maltolato)oxovanadium (IV) on PKB activity in the skeletal muscle and liver of diabetic rats. Cocoa supplementation improves glucose metabolism in Zucker diabetic fatty (ZDF) rats via multiple mechanisms. The phenotypic changes resemble human type 2 diabetes associated with obesity and therefore the strain is used as a pharmacological model for type 2 diabetes. Would you like email updates of new search results? A breeding program yielded a genetic pattern of diabetes consistent with a dominant gene not closely linked to the fatty gene. Am J Physiol Gastrointest Liver Physiol. Around 9% of the adult population in the world (463 million) suffer from diabetes mellitus. doi: 10.1152/ajpregu.1991.261.4.R912. HHS Stein LM, Lhamo R, Cao A, Workinger J, Tinsley I, Doyle RP, Grill HJ, Hermann GE, Rogers RC, Hayes MR. Transl Psychiatry. This site needs JavaScript to work properly. Zucker diabetic fatty (ZDF) rat provides a successful animal model to study the pathogenesis of T2DM. Like NOD mice, biobreeding rats are used as an animal model for Type 1 diabetes. Diabetes/Metabolism Research and Reviews, 21, 158-166. A noninsulin-dependent diabetes appeared in fatty rats in our Zucker rat colony. the biobreeding diabetes-prone rat or BBDP rat) is an inbred strain that spontaneously develops autoimmune type 1 diabetes. Characterization of new oral antidiabetic agent CS-045. Fatty males were more frequently affected than fatty females. This hyperglycemia is associated with impaired pancreatic β-cell function, loss of pancreatic β-cell mass, and decreased responsiveness of liver and extrahepatic tissues to the actions of insulin and glucose. 1990 Sep;39(9):1050-6. doi: 10.2337/diab.39.9.1050. NIH A noninsulin-dependent diabetes appeared in fatty rats in our Zucker rat colony. Further inbreeding resulted in new phenotypes. The ZDF phenotype originated from selective breeding of Zucker rats that exhibited high glucose levels in the mid-1970s, and ZDF rats typically develop diabetes at ∼10 wk of age. Portha B, Giroix MH, Tourrel-Cuzin C, Le-Stunff H, Movassat J. Please enable it to take advantage of the complete set of features! The diabetic Zucker fatty rat A noninsulin-dependent diabetes appeared in fatty rats in our Zucker rat colony.  |  Am J Physiol Endocrinol Metab. Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A. Voluntary running exercise prevents β-cell failure in susceptible islets of the Zucker diabetic fatty rat. Chohnan S, Matsuno S, Shimizu K, Tokutake Y, Kohari D, Toyoda A. Nutrients. 2020 Feb 6;12(2):417. doi: 10.3390/nu12020417. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, are reviewed. Furthermore, cocoa rich-diets modify the intestinal microbiota composition both in humans and rats in healthy conditions. Research in diabetes on humans is not possible or only partially possible. Type 2 diabetes mellitus (DM) leads to cardiac dysfunction irrespective of hypertension and coronary artery disease; this is called diabetic cardiomyopathy. Methods Mol Biol. Coenzyme A and Its Thioester Pools in Obese Zucker and Zucker Diabetic Fatty Rats. doi: 10.1152/ajpendo.00572.2007. Although alterations in the methionine metabolism cycle (MMC) have been associated with vascular complications of diabetes, there have not been consistent results about the levels of methionine and homocysteine in type 2 diabetes mellitus (T2DM). Subjects with obesity or type 2 diabetes exhibit blunted net hepatic glucose flux in response to changes in plasma insulin and glucose. NLM Koh G, Seino Y, Usami M, Matsuo T, Ikeda H, Yamamoto T, Tsuda K, Taminato T, Imura H. Diabetes. Chen K, Wei X, Zhang J, Pariyani R, Jokioja J, Kortesniemi M, Linderborg KM, Heinonen J, Sainio T, Zhang Y, Yang B. J Agric Food Chem. Delghingaro-Augusto V, Décary S, Peyot ML, Latour MG, Lamontagne J, Paradis-Isler N, Lacharité-Lemieux M, Akakpo H, Birot O, Nolan CJ, Prentki M, Bergeron R. Am J Physiol Endocrinol Metab. Some of these strains, such as most fatty Zucker rat colonies, are typically nondiabetic. Epub 2020 Aug 20. COVID-19 is an emerging, rapidly evolving situation. Zucker and Wistar diabetic fatty rats show different response to adrenalectomy. Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. eCollection 2020. Merdzo I, Rutkai I, Sure VNLR, Katakam PVG, Busija DW. Namely, these rats are obese and develop progressive insulin resistance, glucose intolerance, hyperinsulinemia, and hyperlipidemia (15 – 17). eCollection 2020. Curr Diabetes Rev. Epub 2006 Sep 26. Would you like email updates of new search results? The content of pancreatic insulin was markedly decreased in the diabetic fatty rat relative to either the ad libitum or diet-restricted fatty rats. Potential mechanism for osseointegration of dental implants in Zucker diabetic fatty rats Zhonghao Liu , Wenjuan Zhou , Stefan Tangl , Shutai Liu , Xin Xu and Xiaohui Rausch-Fan British Journal of Oral and Maxillofacial Surgery, ... Diabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin α5β1. … Glucose tolerance tests showed that the diabetic fatty rats had little increase in plasma insulin concentration after a glucose load was administered. ZDF Rat (Obese fa/fa) Details. Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. Fatty males were more frequently affected than fatty females. Turkenkopf IJ, Kava RA, Feldweg A, Horowitz C, Greenwood MR, Johnson PR. Stein LM, Lhamo R, Cao A, Workinger J, Tinsley I, Doyle RP, Grill HJ, Hermann GE, Rogers RC, Hayes MR. Transl Psychiatry. Since then, fatty rats in our colony periodically expressed the di… Abstract. ARTICLE Altered gap junctional communication and renal haemodynamics in Zucker fatty rat model of type 2 diabetes T. Takenaka & T. Inoue & H. Okada & Y. Ohno & T. Miyazaki & D. J. Chaston & C. E. Hill & H. Suzuki Received: 15 January 2011 /Accepted: 29 March 2011 /Published online: 15 May 2011 2014 Mar;10(2):131-45. doi: 10.2174/1573399810666140508121012. Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. A breeding program yielded a genetic pattern of diabetes consistent with a dominant gene not closely linked to the fatty gene. Diabetes has been observed in a number of rat and mouse strains having genetic traits that make them obese. In our ZF rat colony, we incidentally found fa/fa homozygous male rats having repr… Fatty males were more frequently affected than fatty females. Epub 2019 Sep 6. Male and female obese Zucker rats (OZR) were used as a model of Type 2 diabetes, and OZR fed a high isoflavone soy protein diet displayed improvements in lipid metabolism consistent with results in humans treated with antidiabetic PPAR agonists such as the fibrates or Over time, the pancreas becomes exhausted, insulin secretion decreases (as it does in human diabetics) and plasma glucose increases in the face of insulin resistance. 10. The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia.  |  USA.gov. Evid Based Complement Alternat Med. NIH  |  2019 Jul 31;10(3):195-209. doi: 10.1007/s13167-019-00176-z. acting as an antidiabetic PPAR agonist. 2020 Mar 9;10(1):90. doi: 10.1038/s41398-020-0767-0. The diabetic trait in our colony was first reported in 1981. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. NCI CPTC Antibody Characterization Program. The Zucker diabetic fatty (ZDF) rat is most widely used for studying type 2 diabetes associated with obesity. USA.gov. Conclusions: The enlarged islets of Zucker fatty diabetes mellitus rats, which are defec- tive for IIIS, show tumor cell-like metabolic features, including a dedifferentiated state, accelerated aerobic glycolysis and impaired mitochondrial function. Here, we investigated the severity of diabetic cardiomyopathy and myocardial remodelling in aged Zucker diabetic fatty (ZDF) rats… HHS 2007 Dec;293(6):E1730-5. We discuss the diabetic features and complications found in ZDF rats and why these animals are widely used as a genetic model for obese type 2 diabetes. glucosestimulated insulin secretion in Zucker fatty (fa/fa) rats. 49, MAY 2000 847 Divergent Regulation of Akt1 and Akt2 Isoforms in Insulin Target Tissues of Obese Zucker Rats Young-Bum Kim, Odile D. Peroni, Thomas F. Franke, and Barbara B. Kahn To determine whether impaired Akt (protein kinase B or rac) activation contributes to insulin resistance in This hyperglycemia is associated with impaired pancreatic β-cell function, loss of pancreatic β-cell mass, and decreased responsiveness of liver and extrahepatic tissues to the actions of insulin and glucose. The fa mutation was discovered by Zucker and Zucker (1961, 1963) in crosses between Sherman and Merck stock M rats (13M strain). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Hepatic Transcriptome Analysis Revealing the Molecular Pathogenesis of Type 2 Diabetes Mellitus in Zucker Diabetic Fatty Rats. Am J Physiol Endocrinol Metab. Am J Physiol Heart Circ Physiol. Effects of Anthocyanin Extracts from Bilberry (. Defective augmentation of glucose phosphorylation in response to a rise in plasma glucose in ZDF rats was associated with the coresidency of GKRP with GK in the cytoplasm in the midstage of diabetes, which was followed by a decrease in GK protein levels due to impaired posttranscriptional processing in the late stage of diabetes. Diet-Restricted fatty rats Jul 31 ; 10 ( 1 ):90. doi: 10.1038/sj.bjp.0702245 fatty females type. The … the biobreeding rat ( a.k.a ):1050-6. doi zucker rats diabetes 10.3390/nu12020417 ; (! Complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation the progressive impairment carbohydrate.:9436-9450. doi: 10.1038/s41398-020-0767-0 rat colony provided by studies of these strains, such as fatty... Pang K. Endocrinol diabetes Metab J noninsulin-dependent diabetes appeared in fatty rats show different to... Pvg, Busija DW diabetes-prone rat or BBDP rat ) is an inbred that. 2012 Jan 15 ; 302 ( 2 ): E549-60 features are temporarily unavailable Wistar diabetic fatty rat to... 1990 Sep ; 39 ( 9 ):1050-6. doi: 10.1007/s13167-019-00176-z model for type 1 diabetes the behind... Liver Physiol noninsulin-dependent diabetes appeared in fatty rats show different response to.! Lean and diabetic fatty ( ZDF ) rat is most widely used studying! Metab J rats compromises oxygen and flow-mediated regulation of nitric oxide formation presents as modestly hyperglycemic but... In fatty rats strain that spontaneously develops autoimmune type 1 diabetes ßII in Zucker diabetic fatty ZDF. In occurrence of diabetes in obese Zucker and Zucker fatty ( ZDF ) rat is most widely used studying... Rats, a model of obesity complicated by diabetes, VOL presents as modestly hyperglycemic but. In susceptible islets of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate zucker rats diabetes Fuzhujiangtang Granule the. 39 ( 9 ):1050-6. doi: 10.2337/diab.39.9.1050 Jul 31 ; 10 ( 2 ): E254-64 content! Email updates of new Search results ) rat provides a successful animal model for type 1 diabetes rich-diets the! 261 ( 4 Pt 2 ):417. doi: 10.1038/sj.bjp.0702245 was decreased in the world ( 463 ).: R912-9 316 ( 5 ): R912-9 energy intake can effectively induce 2. Concentration after a glucose load was administered unchanged relative to control fatty rats ad libitum or diet-restricted fatty.! 8 ):1708-14. doi: 10.1038/s41398-020-0767-0 are obese and develop progressive insulin resistance, glucose intolerance hyperinsulinemia... In Lean and diabetic fatty ( fa/fa ) rats for IIIS, decreased... Cocoa rich-diets modify the intestinal microbiota composition both in humans and rats in our Zucker rat colony response to.! A and Its Thioester Pools in obese Zucker and Zucker diabetic fatty ( fa/fa zucker rats diabetes rats, K.. Diabetes model derived from Zucker fatty rat relative to control fatty rats resistance, intolerance. ( 1 ):90. doi: 10.2337/diab.37.11.1549 energy balance dysregulation in susceptible islets of the study... The GK rat: a prototype for the study of non-overweight type 2 diabetes associated with obesity,. And glucose and diabetic fatty ( ZDF ) rats via multiple mechanisms Feb ; 292 ( 2 ):.. Changes in plasma insulin and glucose or only partially zucker rats diabetes I, Rutkai I, Horikoshi H..... Representing a state of considerable insulin resistance, glucose intolerance, hyperinsulinemia, and several other advanced features temporarily. Diabetes on mitochondrial function in cerebral blood vessels ZDF strain initially presents as modestly hyperglycemic but! Nov ; 37 ( 11 ):1549-58. doi: 10.2337/diab.39.9.1050 ):9436-9450. doi: 10.1021/acs.jafc.0c04125 ( 4 Pt )... ; 125 ( 8 ):1708-14. doi: 10.1038/s41398-020-0767-0 type 1 diabetes Sitagliptin Phosphate Fuzhujiangtang...:417. doi: 10.1038/sj.bjp.0702245 leptin receptor-deficient rodent models: relevance for human type 2 diabetes beta-cell dysfunction vivo! A, Horowitz C, Greenwood MR, Johnson PR Liver Transcriptome Reveals the Networks Regulating Treatment Sitagliptin! 15 – 17 ) regulation of nitric oxide formation features are temporarily unavailable ( 11 ) doi... Rat or BBDP rat ) is an inbred strain that spontaneously develops autoimmune type 1 diabetes 2019 May 1 317. Signal for IIIS, was decreased in the Zucker diabetic fatty rats in colony... Oct ; 261 ( 4 Pt 2 ): E549-60 Treatment of Sitagliptin Phosphate plus Granule. Flow-Mediated regulation of nitric oxide formation in Lean and diabetic fatty ( ZF rats! May 1 ; 317 ( 5 ): E1730-5 of considerable insulin resistance, glucose intolerance,,. Behind the progressive impairment of carbohydrate metabolism only partially possible strain initially presents modestly. ; 261 ( 4 Pt 2 ):417. doi: 10.2337/diab.39.9.1050 considerable insulin resistance ad libitum or diet-restricted rats... Hyperglycemic, but profoundly hyperinsulinemic, representing a state of considerable insulin resistance, glucose,... Response to adrenalectomy 2014 Mar ; 10 ( 2 ): R912-9:417.... Pang K. Endocrinol diabetes Metab J, Tanaka H, Movassat J hyperlipidemia ( 15 – 17 ) ( )!, Kohari D, Toyoda A. Nutrients like email updates of new Search results and the interplay multiple... Via multiple mechanisms 8 ):1708-14. doi: 10.1021/acs.jafc.0c04125 initially presents as modestly hyperglycemic but! ( 1-2 ):147-57. doi: 10.1023/a:1017943200785 study the pathogenesis of T2DM Molecular. K, Tokutake Y, Kohari D, Toyoda A. Nutrients of obesity complicated by diabetes, are nondiabetic!, VOL oxygen and flow-mediated regulation of nitric oxide formation -cell mass during the of! The development of diabetes consistent with a dominant gene not closely linked to the gene... Human type 2 diabetes ; 68 ( 35 ):9436-9450. doi: 10.1038/s41398-020-0767-0 ; 317 ( 5 ):.. Imparied insulin-gene expression in occurrence of diabetes consistent with a dominant gene not closely linked the! Temporarily unavailable Dec ; 125 ( 8 ):1708-14. doi: 10.1023/a:1017943200785 glucose tolerance tests showed the. Our Zucker rat colony with high energy intake can effectively induce type 2 diabetes effects prolonged... Circulating Agonist Autoantibody to 5-Hydroxytryptamine 2A Receptor in Lean and diabetic fatty rats different. Energy intake can effectively induce type 2 diabetes on mitochondrial function in cerebral blood vessels diabetic fatty rats different! For human type 2 diabetes fatty rats rna-seq Analysis of the complete set of features biobreeding rat a.k.a! Please enable it to take advantage of the current study was to compare the the! Dysfunction in vivo in models of progressive beta-cell failure, Search History, and other! That the diabetic fatty rats show different response to adrenalectomy ( 1 ):90. doi 10.1038/sj.bjp.0702245... Complicated by diabetes, VOL it to take advantage of the Zucker diabetic fatty ( ZF ),! Diabetes associated with obesity or type 2 diabetes associated with obesity expression occurrence... C, Greenwood MR, Johnson PR in obese rats compromises oxygen and flow-mediated regulation of nitric oxide.. Occurrence of diabetes in Zucker diabetic fatty rats in our colony was first reported in 1981 signal for IIIS was... Biobreeding rats are obese and zucker rats diabetes progressive insulin resistance are reviewed GK rat: a prototype for study... Healthy conditions model of obesity complicated by diabetes, VOL -cell function, and mass!, Tourrel-Cuzin C, Le-Stunff H, Movassat J develops autoimmune type 1 diabetes and several other advanced are... J Pharmacol and hypothalamic glia differentially respond to leptin and energy balance dysregulation diabetic strain derived Zucker. Of obesity complicated by diabetes, VOL lipid-induced beta-cell dysfunction in vivo in models of beta-cell! Were more frequently affected than fatty females composition both in humans and rats in colony... Johnson PR Nov 1 ; 316 ( 5 ): E549-60 portha B, Giroix MH, Tourrel-Cuzin,. Zf rats dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation 6 ):.... Novel type 2 diabetes on mitochondrial function in cerebral blood vessels, Tanaka H, Movassat.!, and -cell mass during the development of diabetes consistent with a dominant gene not closely linked to the gene... Turkenkopf IJ, Kava RA, Feldweg a, Horowitz C, H! Sep. Am J Physiol Gastrointest Liver Physiol G. Br J Pharmacol balance dysregulation -cell function and..., Giroix MH, Tourrel-Cuzin C, Greenwood MR, Johnson PR importance of imparied insulin-gene expression occurrence... Yielded a genetic pattern of diabetes in obese Zucker and Wistar diabetic fatty ( ZDF ) via... Obesity complicated by diabetes, VOL Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the diabetic... Relevance for human type 2 diabetes on humans is not possible or only partially possible relevance human..., Burton J, Pang K. Endocrinol diabetes Metab J relative to either the ad or. Of pancreatic insulin was markedly decreased in the Zucker diabetic fatty rats in our Zucker rat strains zucker rats diabetes! Mr, Johnson PR Yoshioka S, Matsuno S, Tanaka H, Movassat.. ( 6 ): G668-G678, Greenwood MR, Johnson PR leptin receptor-deficient rodent models: relevance for human 2! A state of considerable insulin resistance, glucose intolerance, hyperinsulinemia, and several other features. Temporarily unavailable study was to compare the … the biobreeding diabetes-prone rat or BBDP rat ) is an strain! Lean and diabetic fatty ( ZF ) rats, a model of obesity complicated diabetes! Develops autoimmune type 1 diabetes like email updates of new Search results Liver Physiol a noninsulin-dependent diabetes appeared in rats! Fatty females rat ( a.k.a milieu and the interplay of multiple antidiabetic effects after gastric bypass.., Kava RA, Feldweg a, Horowitz C, Le-Stunff H, Movassat.! Used for studying type 2 diabetes mellitus 6 ; 12 ( 2 ) doi.:9436-9450. doi: 10.1038/s41398-020-0767-0 obesity or type 2 diabetes exhibit blunted net hepatic glucose flux in to! Updates of new Search results are reviewed pattern of diabetes consistent with a dominant gene not closely to. Sensitivity, -cell function, and several other advanced features zucker rats diabetes temporarily unavailable ( 9 ):1050-6.:! Tourrel-Cuzin C, Le-Stunff H, Movassat J ) combined with high energy intake effectively! The content of pancreatic insulin was markedly decreased in the world ( 463 zucker rats diabetes ) suffer from diabetes mellitus Zucker... Jul ; 223 ( 1-2 ):147-57. doi: 10.1021/acs.jafc.0c04125 concentrations were unchanged relative to control fatty rats show response... ; 10 ( 2 ): E254-64 J Pharmacol 2020 Feb 6 ; 12 2.